I've pointed out on a couple of Stacks that have discussed this study that 2/3 of the study pop were vaccinated, and there is no recording of how recent that was in relation to their COVID diagnosis. It's obvious at this point that vaxxing has a huge impact on immune status, so I don't see how this study has any validity with regard to other treatments. But the one thing you could compare is the totally unvaxxed participants. Among those, 1 died in IVM group, 3 in placebo. That's buried in the supplemental tables #6.
Ivermectin worked great for my husband and myself when we got the Delta variant. took it early, still felt crappy, but recovered in a week and no long term issues.
Feb 21, 2022·edited Feb 21, 2022Liked by Igor Chudov
Thank you! I’m glad someone told the truth while cnn and Others right here on substack just flat out claimed ivermectin did not work! What a bunch of crap. So sick of this political bullshit while people die who obviously CAN be helped!!!
Thank you for researching this study and revealing such a major flaw. The conclusion of the study has been getting a lot of promotion by those who have an interest in dismissing Ivermectin as an early treatment for Covid-19.
It appears the best results with ivermectin occur when taken prophylactically or immediately after exposure. Failing that as soon as any type of symptom appear.
Igor, you have to dig into the supplementary data, but if you look at eTable 3, you can find CRP data. Though the difference between treatment and control groups was not significant (p=0.20), as with the vent and mortality data, the trend was in the direction you'd expect if ivermectin had an anti-inflammatory effect. In the IVM arm, baseline CRP was 2.82 and ended at 3.16. While that's an increase, it was less than the control where baseline was 2.76 and increased to 3.65 on Day 5. But look also at the 95% confidence interval. The IVM arm was (-0.19 to 0.86) while the control arm was (0.22 to 1.56). In other words, some of the IVM patients saw a reduction in CRP, but the control arm patients did not (at least at the 95% C.L.). So, tighter confidence interval, lower mean, and negative lower limit indicating a reduction due to IVM. This finding supports the reduced vent and mortality data, since hyperinflammation is the root cause of most COVID deaths.
At this point in time, I wouldn’t trust any major/established journals. just like mainstream media outlets, they have been captured. Due diligence is vital. It’s the alternative media such as Igor’s substack and “smaller” journals that are seeking the facts and the truth.
I is think it is likely worth looking at the retracted hydroxychlotinwuine study from that time Trump did his work on ensutimg that treatment was not available . They set up that study to show it was contra indicated for use . And I am suggesting this study was also set up to demonstrate that ivermectin should be contraindicated for use . But it did not do that . It failed to show ivermectin should he listed as contraindicated for the treatment of covid !
Igor, you are joining the greats up there with boriquagato in doing a great job dissecting this information and sharing it with your readers. Maybe Alex "Horse Dewormer" Berenson could learn a thing or 2.
It's a miracle IVM worked at that late stage when antihistamine and steroids are more appropriate. But hey - I'll take it any day, considering risk is almost non-existent.
Alex Berenson, are you reading? Or still too invested in trying to play “gotcha” with Dr. Robert Malone?
I've pointed out on a couple of Stacks that have discussed this study that 2/3 of the study pop were vaccinated, and there is no recording of how recent that was in relation to their COVID diagnosis. It's obvious at this point that vaxxing has a huge impact on immune status, so I don't see how this study has any validity with regard to other treatments. But the one thing you could compare is the totally unvaxxed participants. Among those, 1 died in IVM group, 3 in placebo. That's buried in the supplemental tables #6.
Ivermectin worked great for my husband and myself when we got the Delta variant. took it early, still felt crappy, but recovered in a week and no long term issues.
Thank you! I’m glad someone told the truth while cnn and Others right here on substack just flat out claimed ivermectin did not work! What a bunch of crap. So sick of this political bullshit while people die who obviously CAN be helped!!!
Thank you for researching this study and revealing such a major flaw. The conclusion of the study has been getting a lot of promotion by those who have an interest in dismissing Ivermectin as an early treatment for Covid-19.
I wonder if Alex Berenson reads your and Jessica’s substack?
It appears the best results with ivermectin occur when taken prophylactically or immediately after exposure. Failing that as soon as any type of symptom appear.
Fantastic break down, Igor
Thank you!
Igor, you have to dig into the supplementary data, but if you look at eTable 3, you can find CRP data. Though the difference between treatment and control groups was not significant (p=0.20), as with the vent and mortality data, the trend was in the direction you'd expect if ivermectin had an anti-inflammatory effect. In the IVM arm, baseline CRP was 2.82 and ended at 3.16. While that's an increase, it was less than the control where baseline was 2.76 and increased to 3.65 on Day 5. But look also at the 95% confidence interval. The IVM arm was (-0.19 to 0.86) while the control arm was (0.22 to 1.56). In other words, some of the IVM patients saw a reduction in CRP, but the control arm patients did not (at least at the 95% C.L.). So, tighter confidence interval, lower mean, and negative lower limit indicating a reduction due to IVM. This finding supports the reduced vent and mortality data, since hyperinflammation is the root cause of most COVID deaths.
Great catch, Igor! I spent a good part of the afternoon today looking at this study and did not catch that.
At this point in time, I wouldn’t trust any major/established journals. just like mainstream media outlets, they have been captured. Due diligence is vital. It’s the alternative media such as Igor’s substack and “smaller” journals that are seeking the facts and the truth.
I is think it is likely worth looking at the retracted hydroxychlotinwuine study from that time Trump did his work on ensutimg that treatment was not available . They set up that study to show it was contra indicated for use . And I am suggesting this study was also set up to demonstrate that ivermectin should be contraindicated for use . But it did not do that . It failed to show ivermectin should he listed as contraindicated for the treatment of covid !
I think it’s worth calling it out .
The authors and JAMA would prefer to be in the control group.
When will it become unethical to conduct a RCT of ivermectin because we know many of those who get the placebo will die?
Igor, you are joining the greats up there with boriquagato in doing a great job dissecting this information and sharing it with your readers. Maybe Alex "Horse Dewormer" Berenson could learn a thing or 2.
It's a miracle IVM worked at that late stage when antihistamine and steroids are more appropriate. But hey - I'll take it any day, considering risk is almost non-existent.
Good stuff, Igor'.