The biology for this is plausible at an elevator pitch level.
Binding to the nsp5 / 3C-Like protease just pauses the virus's work within cells. This occurs after the polyprotein is formed but before nsp5 has chopped it up into little parts (including more nsp5's). So by pausing matters here, it's just a matter of what has a higher half-life in the body/cells - the drug, or the RNA and un-processed polyproteins of the virus? Presumably the polyproteins will still be cleaved at a lower rate by endogenous proteases that are expressed (*edit, actually by auto-cleavage; revised version of the mechanism here https://unglossed.substack.com/p/unfinished-business). This releases fresh nsp5. Viral replication takes off a little bit behind of where it left off (minus some degraded RNA). So the drug has to be taken for longer (until all the RNA is broken down) or forever, who knows.
All antiviral treatments that attack the processes of viral replication are subject to these types of paradoxes, because viruses replicate using the same processes our cells use to do everyday work.
My caveats would be that I'm always a little skeptical that drugs actually do what they promise on a molecular level most times to begin with, and I haven't researched Paxlovid very much.
Sadly, I know someone who got sick with a somewhat mild case of Covid in January, but she was concerned about it worsening due to some co-morbidities and she was in her 50s. She said on FB that her doctor told her that Paxlovid "works better for Omicron," so her husband drove several hundred miles across a few states overnight to get her some Paxlovid because she said she wasn't able to get it in our area and just wanted to be sure that she "threw everything at it" because of her co-morbidities. She initially improved after taking Paxlovid, but then suddenly took a turn for the worse, and just like that shockingly ended up in the hospital on a ventilator and died a week to 10 days later, so this article explains a lot.
Thanks for another interesting article. Sorry to hear Twitter blocked you, but as someone at Babylon Bee said, "The only thing better than building a Twitter account with 100k followers is having your account blocked because you spoke the truth." (Or something like that).
Really angry you got banned from Twitter Censorship on Critical Thinking Police. FYI I am happy to tweet whatever you want on Twitter. Censorship goes against my values so Im here if you want anything tweeted. Just tweeted this article.
I would need to look deep into the mechanisms, but if this is allowing the virus to still enter cells, and just stop working inside them, you know exactly what I think. The virus will start doing the weird "apoptosis roulette" and causing low grand long term inflammation. Great one 👍🏻
Thank you for reading reddit and twitter so we don't have to.
How long until someone earnestly argues that a "quick and thick" positive on a lateral flow test while on paxlovid means it's working?
As an aside, I was always troubled by the fact that antivirals for flu treatment require early treatment, but doctors are dissuaded from treating flu at all except for the seriously immunocompromised. What I failed to realize is that the approved antivirals might not work (to put it mildly). It's as if the whole market for these compounds was to get govts to stockpile them, not to treat people.
Made me laugh your banned off twitter today, as I was yesterday, truth hurts doesn't it.
It's the same with molnupiravir. When you look into its history and find that is mutagenic. Yet repurposed and EUA. Everything they do to help, actually increases the risk.
The biology for this is plausible at an elevator pitch level.
Binding to the nsp5 / 3C-Like protease just pauses the virus's work within cells. This occurs after the polyprotein is formed but before nsp5 has chopped it up into little parts (including more nsp5's). So by pausing matters here, it's just a matter of what has a higher half-life in the body/cells - the drug, or the RNA and un-processed polyproteins of the virus? Presumably the polyproteins will still be cleaved at a lower rate by endogenous proteases that are expressed (*edit, actually by auto-cleavage; revised version of the mechanism here https://unglossed.substack.com/p/unfinished-business). This releases fresh nsp5. Viral replication takes off a little bit behind of where it left off (minus some degraded RNA). So the drug has to be taken for longer (until all the RNA is broken down) or forever, who knows.
All antiviral treatments that attack the processes of viral replication are subject to these types of paradoxes, because viruses replicate using the same processes our cells use to do everyday work.
My caveats would be that I'm always a little skeptical that drugs actually do what they promise on a molecular level most times to begin with, and I haven't researched Paxlovid very much.
The theme of the week is...SNAKE PRODUCTS.
Sadly, I know someone who got sick with a somewhat mild case of Covid in January, but she was concerned about it worsening due to some co-morbidities and she was in her 50s. She said on FB that her doctor told her that Paxlovid "works better for Omicron," so her husband drove several hundred miles across a few states overnight to get her some Paxlovid because she said she wasn't able to get it in our area and just wanted to be sure that she "threw everything at it" because of her co-morbidities. She initially improved after taking Paxlovid, but then suddenly took a turn for the worse, and just like that shockingly ended up in the hospital on a ventilator and died a week to 10 days later, so this article explains a lot.
Thanks for another interesting article. Sorry to hear Twitter blocked you, but as someone at Babylon Bee said, "The only thing better than building a Twitter account with 100k followers is having your account blocked because you spoke the truth." (Or something like that).
So sad this needs repeating:
"Just to remind everyone, we have “symptoms”, such as fever, because our immune system is working to counter the infection and kill off the pathogen.
Having no symptoms and no infection is a good thing. Having no symptoms and an ongoing, contagious Covid infection is a bad thing."
Seems the creation of asymptomatic spreaders is the common theme among all of their big ideas. Almost as if it’s by design.
Blocked on twitter?
You must be telling the truth.
Really angry you got banned from Twitter Censorship on Critical Thinking Police. FYI I am happy to tweet whatever you want on Twitter. Censorship goes against my values so Im here if you want anything tweeted. Just tweeted this article.
The Medical Mafia in Action - Offering Isotropic Humanicide Services Worldwide
.
AMA = American Murder Association
CDC = Center for Death and Corruption
DIC = Drugs Industrial Complex
DHS = Defense for Humanicide Services
FDA = Fraud and Death Association
HHS = Holistic Humanicide Services
MD = Most Deplored
NIAID = Novel Inquisition for Allergic and Infectious Dogmas
NIH = Nihilism In Healthcare
NSFW = Not Safe For Work
WHO = William Henry (III)'s Omnipotence
Dr. Red Pill Fact Check:
Glendale Adventist Hospital
https://stevekirsch.substack.com/p/vax-injured-person-gets-appalling?s=r
These people deserve the credit for the deaths of nearly a million Americans
https://stevekirsch.substack.com/p/these-people-deserve-the-credit-for?s=r
70% of Americans are on at least one prescription drug.
The sicker America is, the richer the Drugs Industrial Complex (DIC)
No curing is allowed, ever. Treating symptoms assures recurring revenues.
Natural healing methods are relegated to Quackery.
An empire of Lies, Corruption, Degeneracy, and Death run by a Covidian Cult.
NB: You’re free to post the above text anywhere free speech is tolerated.
Never take a new-to-market drug. Never.
I would need to look deep into the mechanisms, but if this is allowing the virus to still enter cells, and just stop working inside them, you know exactly what I think. The virus will start doing the weird "apoptosis roulette" and causing low grand long term inflammation. Great one 👍🏻
Sigh... humans in their quest to never die or feel sick will take any drug under the sun. As a result, they never live.
Thank you for reading reddit and twitter so we don't have to.
How long until someone earnestly argues that a "quick and thick" positive on a lateral flow test while on paxlovid means it's working?
As an aside, I was always troubled by the fact that antivirals for flu treatment require early treatment, but doctors are dissuaded from treating flu at all except for the seriously immunocompromised. What I failed to realize is that the approved antivirals might not work (to put it mildly). It's as if the whole market for these compounds was to get govts to stockpile them, not to treat people.
Made me laugh your banned off twitter today, as I was yesterday, truth hurts doesn't it.
It's the same with molnupiravir. When you look into its history and find that is mutagenic. Yet repurposed and EUA. Everything they do to help, actually increases the risk.
Keep up the excellent work Igir💪
"blocked by Twitter"
#MeToo
Guess Elon Musk's Twitter stake is like Paxlovid. Censorship symptoms still persist.
The Parag virus needs to be cleared.
unfortunately paxlovid does not suppress curiosity.